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But you can do even more
By using a simple probiotic supplement you can help establish and grow a colony of this precious little helper bacterium in your body by something as simple as taking 1 pill per day.
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Akkermansia muciniphila is a gram negative mucin-degrading bacterium that is a natural resident in the human gut biome. Unhealthy living and unnatural diets play a key role in the decimation of this very important bacterium that our immune system benefits from so much. By developing an imbalance in the bacterial biome the human immune system gets out of balance, which not only may result in various health issues for the individual beeing but also might play a hindering role in some forms of cancer treatments.
A. muciniphila is part of the normal gut microbiota composition in about 90% of healthy individuals [1]. However the levels of population vary greatly and about 10% of people seem to be missing Akkermansia municiphila in general.
One factor that has been studied in mice, is an increased abundance of A. muciniphila that might be correlated or a result of western high fat high proteine diet.
A Western high-fat diet on Apoe−/−mice for 8 weeks reduced the abundance of A. muciniphila from around 7.0 × 109/g feces to 4.6 × 109/g feces, an over 100-fold decrease. While, supplementation with A. muciniphila (5 × 109 cfu for 8 weeks) on the Western diet was able to restore the abundance of A. muciniphila back to 8.0 × 109/g feces (Li et al., 2016).
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC6223323/
An interesting thing about this microorganism is that it resides entirely within the mucus layer, or mucosa, of the gut wall (muciniphila literally means mucus-loving) rather than in the feces.
The past
Scientists have revealed, that probiotic intake of Akkermansia muciniphila may not just strengthen the human immune system but also that it can play a big supporting role in the treatment of cancer.
While all this information is available to the public for some years now, the former only effective application form was the transplantation of stool, which a lot of people found disgusting and didn’t want to undergo.
Today
It was not that long ago, that scientists have created a more easy way to supplement the human body with this bacterium. They created a probiotic supplement people could swallow like a pill with large amounts of pasteurized Akkermansia muciniphila.
This way people having no natural or only a low amount of Akkermansia bacteria inside their gut system, may supplement and try to establish a healthy population that might result in various health benefits for your body.
The following products are available in 🇺🇸
Pendulum Therapeutics Inc. on Amazon.com
The Akkermansia Company on Amazon.com
The future of cancer treatment with Akkermansia municiphila
Strain-specific mechanisms: Scientists are about to identify which strains of A. muciniphila are the most effective ones in cancer therapy.
Personalized microbiome-based therapies: Given the variability in patient responses to A. muciniphila, microbiome-based interventions tailored to individual patients could enhance therapeutic outcomes. Personalized dietary strategies or probiotics aimed at optimizing A. muciniphila levels should be explored to maximize its cancer-fighting potential.
What you can do to help your microbiome get in balance
Everyone may contribute to the microbial balance by eating a healthy diet. There are some foods, that have been scientifically proven to support the growth of Akkermansia muciniphila and retain an intact and more balanced microbiome in the gut of mice.
These foods may help humans to maintain high levels of Akkermansia muciniphila:
- Cranberries
- Concord grape polyphenols
How to establish a culture of Akkermansia Municiphila in the first place
While around 90% of humans have this bacterium in their gut, however the level of population by Akkermansia municiphila is way too low in a lot of cases and 10% of humans miss this bacterium alltogether. The easiest way is to use a supplement in form of an Akkermansia probiotic. It is as easy as swallowing a pill a day for at least a month or a couple months in a row.
Usage of some antibiotics or other medicine might also kill the strain while an unhealthy diet reduces its chance of survival and growth. Which is why using a probiotic supplement including this healthy bacterium on a regular base can play a key role in increasing gut health and immune responses.
In your country 🇺🇸 the following products are available:
Pendulum Therapeutics Inc. on Amazon.com
The Akkermansia Company on Amazon.com
Ways to increase the abundance of Akkermansi muciniphila:
Eat foods high in prebiotic fibers and FODMAPs, e.g. onions, garlic, asparagus, pears, dried fruit [25].
Eat more dietary polyphenols from foods like cranberry and pomegranate juices and extracts, green tea and red grapes, or red wine [27]. Caveat: Data is from healthy mouse models; studies in humans and diet-induced obese mice haven’t shown a significant change in Akkermansia levels to date.
Try intermittent fasting [28].
Take up regular aerobic exercise that ideally mixes easier and higher intensity activities [29].
What probiotics can do
This may be as simple as taking more established probiotics. For example, in a small study, people with type-1 diabetes who took Lacto-Bifido probiotics for 6 months also saw an increase in their Akkermansia levels [24].
This information is backed by scientific research, as you can read about here: https://pmc.ncbi.nlm.nih.gov/articles/PMC6223323
Akkermansia muciniphila (A. muciniphila), regarded as a promising candidate for next-generation probiotic applications, predominantly inhabits the intestinal mucus layer, where it plays a crucial role in maintaining gut barrier integrity and modulating immune responses. Recently, the bacterium has been recognized for its ambivalent influence on cancer, impacting both tumor progression and therapeutic interventions. Research indicates that A. muciniphila might possess both tumorigenic and anticancer capabilities, influenced by factors such as the composition of the gut microbiota, dietary modifications, and immune modulation. There is a compelling need for further studies to uncover the precise mechanisms and optimal use of A. muciniphila in oncology and beyond.
Quote from: https://onlinelibrary.wiley.com/doi/full/10.1002/imo2.70010
The human microbiome has emerged as a crucial determinant of health, with the gut microbiota playing a significant role in various diseases, including cancer [1]. Among the many microbiota inhabitants, Akkermansia muciniphila (A. muciniphila), a Gram-negative, mucin-degrading bacterium, has attracted considerable attention due to its multifaceted roles in gut health and its ambivalent relationship with cancer. This Commentary delves into the dual nature of A. muciniphila‘s influence on cancer, exploring its mechanisms in both promoting and inhibiting tumorigenesis, as well as its therapeutic potential and the challenges that remain for clinical application.
Moreover, A. muciniphila plays a key role in modulating the immune system [4]. It has been shown to activate regulatory T cells (Tregs), which are critical for maintaining immune tolerance and preventing chronic inflammation—a key driver of cancer progression. Additionally, A. muciniphila has been linked to enhanced immune checkpoint inhibition efficacy, particularly in cancers treated with immune checkpoint inhibitors like anti-PD-1/PD-L1 antibodies. This bacterium influences the gut immune system, potentially improving the host’s response to cancer treatments, and making it an exciting candidate for combination therapies with immune checkpoint inhibitors. The multifaceted physiological roles of A. muciniphila are further illustrated in Figure 1B.
While the product of Akkermansia Probiotics is pretty new and very promising, not every product has been certified as a supplement in all countries.
In your country 🇺🇸 the following products are available:
Pendulum Therapeutics Inc. on Amazon.com
The Akkermansia Company on Amazon.comIn your country 🇺🇸 the following products are available:
Pendulum Therapeutics Inc. on Amazon.com
The Akkermansia Company on Amazon.com
In your country 🇺🇸 the following products are available:
Pendulum Therapeutics Inc. on Amazon.com 
The Akkermansia Company on Amazon.com
Fight cancer by boosting your immune system with increasing gut health
Help Akkermansia grow and balance out your micro-biome for health benefits
Wäre auch gut zur Einleitung:
https://www.youtube.com/embed/-aP2VvEWHAc
Listen what Dr. Emily has to say about the Wonder-Bacterium Akkermansia
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Explanation of how it works:
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Last resort zum überwältigen:
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